Collegium Helveticum
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Workshop

Sample Delivery Methods
For In-Situ Studies and Serial Crystallography

Details

Public event, free of charge.

X-ray Free Electron Lasers (XFEL) can generate extremely bright and ultrafast X-ray pulses to determine structural properties of complex biomolecules at an atomic scale, and, create ‘molecular movies’ capturing rapid chemical processes with unprecedented temporal resolution. The high intensity of the X-rays destroys the studied samples immediately after detailed information is extracted. Consequently, fresh samples need to be delivered continuously, in sync with incoming X-ray pulses. This constitutes a key challenge for XFEL data collection.

This workshop brings together chemists, structural biologists, beamline scientists, and engineers to explore the latest advancements in sample delivery techniques for X-ray sources, with a specific focus on in-situ monitoring of bio-chemical reactions and serial crystallography.

Program

14:00

Opening and welcome remarks

Tuncay Alan

14:05

Droplet-Based Microfluidics for High-Throughput Chemistry

Andrew deMello
ETH Zurich

14:35

Science in Arts and the Art of Science
Injecting Carpets and Microdroplets in X-Ray Microscopes

Thomas Huthwelker
Paul Scherrer Institute, CH

14:55

Sample Delivery Methods for Protein Crystallography at SwissFEL Alvra

Emma Victoria Beale
SwissFEL & Paul Scherrer institute, CH

15:15

Coffee break

15:25

High Repetition Rate (And Other) Sample Delivery for European XFEL

Joachim Schulz
European XFEL, DE

15:55

Imaging Isolated Nanoparticles and Their Ultrafast Dynamics

Daniela Rupp
ETH Zurich, CH

16:15

The XFEL Hub at Diamond
Dynamic Structural Biology on Earth

Allen Orville
Diamond Light Source, UK

16:45

Developing Fixed-Target Instrumentation for Time-Resolved Crystallography at the Swissfel Cristallina Experimental Station

Michal Kepa
Paul Scherrer Institute, CH

17:05

Closing remarks

Followed by a small reception with drinks.

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